# MLR Review

> Published by **Knowledge Company** (knowledgecompany.ai).
> Canonical source: https://knowledgecompany.ai/dictionary/mlr-review
> Markdown mirror, generated 2026-09-02. Cite the canonical URL.

The medical, legal and regulatory sign-off that life-sciences companies require before any external-facing claim is published.

Governance

OWNER — Research

LAST REVIEWED — 2026-09-02 19:07:16 UTC

[SOURCE — eCFR — 21 CFR § 202.1, Prescription-drug advertisements ↗](https://www.ecfr.gov/current/title-21/chapter-I/subchapter-C/part-202/section-202.1)

## What it is

MLR review is the medical, legal and regulatory sign-off that life-sciences companies require before any external-facing claim is published. Medical reviewers check that the science supports the statement, legal checks promotion law and intellectual property, and regulatory checks labelling and advertising rules such as 21 CFR 202.1. Nothing reaches a customer without passing all three.

## Why it matters

MLR is the closest working precedent for what claim governance looks like when being wrong is a regulatory event rather than a reputational one. It is also slow and expensive, which is why no other industry has adopted it wholesale. The useful question is not whether to copy it but which parts of it — the claim-level granularity, the evidence link, the expiry — can be made automatic enough to be worth running outside a regulated market. That is the question Knowledge Company exists to answer.

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## Related documents in this mirror

- [Dictionary](https://llms.knowledgecompany.ai/dictionary.md)
- [Approved Claim](https://llms.knowledgecompany.ai/dictionary/approved-claim.md)
- [Source of Truth](https://llms.knowledgecompany.ai/dictionary/source-of-truth.md)
- [Knowledge Drift](https://llms.knowledgecompany.ai/dictionary/knowledge-drift.md)
- [Retrieval Boundary](https://llms.knowledgecompany.ai/dictionary/retrieval-boundary.md)
- [Claim Registry](https://llms.knowledgecompany.ai/dictionary/claim-registry.md)
- [Substantiation](https://llms.knowledgecompany.ai/dictionary/substantiation.md)
- [Claim Owner](https://llms.knowledgecompany.ai/dictionary/claim-owner.md)

*This document is the markdown mirror of https://knowledgecompany.ai/dictionary/mlr-review, published by Knowledge Company -
a knowledge freshness platform that detects, verifies and updates outdated claims in company content.*

*Mirror index: https://llms.knowledgecompany.ai/index.md - Generated 2026-09-02*